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KMID : 0043320090320020185
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Archives of Pharmacal Research
2009 Volume.32 No. 2 p.185 ~ p.190
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Immunosuppressive Effects of New Cyclolanostane Triterpene Diglycosides from the Aerial Part of Cimicifuga foetida
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Cao Li
Li Zhan
Zhao Xiao-Hong
Si Jian-Yong
Chen Di-Hua
Pan Rui-Le
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Abstract
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Two new cyclolanostane diglycosides, cimifoetiside A (1) and cimifoetiside B (2), were isolated from an 80% ethanolic extract of the aerial part of Cimicifuga foetida L. (Ranuculaceae). Using spectral data and chemical analysis, the structures of 1 and 2 were identified as (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→3’)-β-D-xylopyranoside and (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→2’)-β-D-xylopyranoside, respectively. The in vitro immunosuppressive effects of the two new compounds 1 and 2, as well as four other known cyclolanostane saponins 3-6 on T cells were evaluated. All the agents tested effectively inhibited the proliferation of murine splenocytes induced by Concanavalin A (ConA), with IC50 values ranging from 12.7 nM to 33.3 nM.
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KEYWORD
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Cimicifuga foetida, Ranunculaceae, Cyclolanostane triterpene diglycosides, CimifoetisideA/B, Immunosuppressive effect
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